New Dataset Provides a New Resource for Genetic and Epigenetic Insights into sporadic ALS

Feró O, Varga D, Nagy É, Karányi Z, Sipos É, Engelhardt J, Török N, Balogh I, Vető B, Likó I, Fóthi Á, Szabó Z, Halmos G, Vécsei L, Arányi T, Székvölgyi L. DNA methylome, R-loop and clinical exome profiling of patients with sporadic amyotrophic lateral sclerosis. Sci Data. 2024 Jan 24;11(1):123. doi: 10.1038/s41597-024-02985-y. PMID: 38267456.

Summary

The article presents a comprehensive epigenomic study by the labs of Drs. Lóránt Székvölgyi and Tamás Arányi. It focuses on analyzing molecular factors in sporadic ALS patients using techniques like Clinical Exome Sequencing, DNA-RNA hybrid immunoprecipitation sequencing, and Reduced Representation Bisulfite Sequencing. The study aims to uncover genetic and epigenetic changes associated with ALS, potentially aiding in understanding the disease's causes and developing new therapies.

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