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Aaron Haeusler Research

Identifying neurodegenerative

mechanisms and interventions for ALS and FTD

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Research

We are motivated and driven to understand how molecular mechanisms drive disease in patients with ALS/FTD. Our primary research goal is to identify the molecular cascade of pathogenic events that are initiated in these debilitating diseases in efforts to develop efficacious therapeutic strategies.

Latest Publications

Neuronal activity-dependent gene dysregulation in C9orf72 i3Neuronal models of ALS/FTD pathogenesis
Layla Ghaffari et al. 2025. AJP – Cell Physiology

Our recent study using iPSC-derived cortical neurons reveals how neuronal activity drives gene dysregulation in C9ORF72-linked ALS/FTD. We uncover synaptic dysfunction, peroxisomal dysregulation, and NPAS4-linked transcriptional shifts, highlighting key disease-modifying pathways. Explore our research and generate your own discoveries using our interactive dataset included in the link in the article.

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Contact us

email: AaronHaeusler at gmail dot com

Disclaimer: The views expressed on this website are my own and may not reflect the views shared by the Weinberg ALS Center, the Sidney Kimmel Medical College, the Vickie and Jack Farber Institute for Neuroscience, nor Thomas Jefferson University.

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